Related Experiment Video
Updated: Apr 12, 2026
High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
Brain Atrophy Can Predict the Severity and Prognosis of Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Yinyao Lin1, Haiyan Li1, Yanling Li2
1Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Background And Purpose:
Compare clinical and lab characteristics of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis cases with and without brain atrophy.
Methods:
Assess cerebral atrophy using median temporal lobe atrophy (MTA) and global cortical atrophy (GCA) scores in 82 anti-NMDAR encephalitis cases.
Results:
GCA (+) cases had higher proportions of status epilepticus (p<0.001), memory problems (p=0.031), sepsis (p<0.001), and mechanical ventilation need (p=0.001) than GCA (-) cases. MTA (+) cases had higher memory problems (p<0.001) and sepsis (p=0.002) than MTA (-) cases. GCA (+) and MTA (+) groups had higher max modified Rankin Scale (mRS) (p<0.001, p=0.002) and 1-year mRS (p<0.001, p=0.004) scores than GCA (-) and MTA (-) groups. GCA (+) group had a longer hospital stay and a larger proportion of cases with limited treatment response (both p<0.001) than the GCA (-) group. GCA (p=0.005) was found to be a significant predictive factor for the mRS score 1 year after onset in multiple linear regression analysis.
Conclusions:
MTA and GCA may be associated with severity and prognosis in anti-NMDAR encephalitis.
