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Updated: Sep 9, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Anticipated Out-Of-Pocket Costs and Prostate Cancer Management Among Men With Commercial Insurance.

Sarah Leick1, Addison Shay2, Samuel R Kaufman2

  • 1Department of Urology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Cancer Medicine
|August 29, 2025
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Summary
This summary is machine-generated.

For men with prostate cancer, out-of-pocket costs vary but do not significantly influence the decision between immediate treatment and conservative management. Financial liability appears inelastic to treatment choices.

Keywords:
financial toxicityinsurance designout‐of‐pocket costsprostate cancer

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Area of Science:

  • Oncology
  • Health Economics
  • Health Services Research

Background:

  • Newly diagnosed prostate cancer patients choose between immediate treatment and conservative management.
  • Out-of-pocket costs differ significantly between these management strategies.
  • Anticipated patient costs may influence treatment decisions.

Purpose of the Study:

  • Estimate out-of-pocket costs for commercially insured men with newly diagnosed prostate cancer.
  • Measure the association between predicted patient costs and the choice of immediate treatment versus conservative management.

Main Methods:

  • Utilized MarketScan data (2010-2020) for men with prostate cancer.
  • Derived cost prediction coefficients from arthroscopic meniscal repair patients.
  • Applied coefficients to estimate prostate cancer patients' out-of-pocket costs and used logistic regression to assess treatment choice.

Main Results:

  • Identified 58,206 men with prostate cancer.
  • 12% had zero predicted out-of-pocket costs; median cost was $350 for others.
  • Adjusted immediate treatment rates ranged narrowly from 77.8% to 78.6% across cost quartiles.

Conclusions:

  • Predicted out-of-pocket costs for prostate cancer management vary widely among commercially insured men.
  • Treatment choice (immediate vs. conservative) appears insensitive to anticipated patient financial liability.