Evaluating the Implementation Success of an Intensity-Adapted Guideline for Pediatric Acute Myeloid Leukemia in...

Area of Science:

• Pediatric Oncology
• Implementation Science
• Hematology

Background:

• Acute myeloid leukemia (AML) presents significant treatment challenges in low-resource settings.
• The International Society of Paediatric Oncology (SIOP) developed an adapted AML practice guideline in 2019 to improve outcomes.
• There is a need to evaluate the effectiveness of adapted guidelines in resource-limited environments.

Purpose of the Study:

• To present the protocol for an observational-implementation study evaluating the SIOP AML guideline in Malawi.
• To propose hybrid effectiveness-implementation designs for evaluating pediatric hematology-oncology interventions in low-resource settings.
• To generate evidence for adopting adapted treatment strategies in resource-limited contexts.

Main Methods:

• Observational-implementation study design.
• Evaluation of the SIOP adapted AML practice guideline.
• Application of hybrid effectiveness-implementation designs.

Main Results:

• The study protocol is presented for evaluating the SIOP AML guideline in Malawi.
• Hybrid designs are proposed as a method for evaluating adapted treatment strategies.
• This approach is adaptable to various pediatric hematology-oncology diseases and contexts.

Conclusions:

• The proposed hybrid designs offer a novel approach for evaluating interventions in low-resource settings.
• This study aims to inform the adoption of adapted treatment strategies for pediatric AML.
• The methodology can be applied broadly to pediatric hematology-oncology in resource-limited areas.