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Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

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Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
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Factors Affecting Illness01:18

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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[Immune profiles of patients with juvenile depression: association with clinically high risk of psychosis manifestation].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
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[Neurobiological basis of suicidal behavior in adolescents].

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Related Experiment Video

Updated: Sep 9, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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[Factors supporting chronic inflammation in mental illness].

T P Klyushnik1, V O Generalov1, T E Obodzinskaya1

  • 1Medline LLC, PlanetaMed Clinic, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|August 29, 2025
PubMed
Summary

Chronic inflammation, influenced by factors like infections and stress, worsens mental illness. Targeting these factors alongside treatment can improve outcomes and overcome therapy resistance.

Keywords:
autismdepressioninfectionsmaintenance of chronic inflammationmicrobiomephysical inactivityschizophreniastress

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Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Chronic inflammation is increasingly recognized as a significant factor in the development and progression of mental illnesses.
  • Factors such as infections, gut microbiome dysbiosis, physical inactivity, obesity, chronic stress, and metabolic imbalances contribute to lifelong inflammation.
  • This inflammation can exacerbate mental health conditions and hinder treatment efficacy.

Purpose of the Study:

  • To review the factors and mechanisms through which chronic inflammation influences mental illness severity and progression.
  • To explore how targeting these inflammatory factors can complement standard pharmacotherapy for mental disorders.

Main Methods:

  • A comprehensive literature review was conducted.
  • Key factors contributing to chronic inflammation and their impact on mental health were identified and analyzed.
  • Mechanisms linking inflammation to mental illness pathogenesis were examined.

Main Results:

  • Identified key contributors to chronic inflammation including infections, gut microbiome disorders, sedentary lifestyle, overweight, chronic stress, and metabolic imbalance.
  • Established the link between these factors, heightened inflammation, and the aggravation of mental illness.
  • Demonstrated that addressing these factors can lead to a milder disease course.

Conclusions:

  • Targeting factors contributing to chronic inflammation offers a promising adjunctive strategy to standard drug therapy for mental illnesses.
  • Interventions aimed at reducing inflammation can improve the quality and duration of remissions.
  • This approach may help overcome treatment resistance in some cases.