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Elezanumab Accelerates Post-Injury Regeneration of Olfactory Sensory Neurons in a Methimazole-Induced Mouse Model
Eri Mori1,2, Rumi Ueha2,3, Hirotaka Tanaka1,2
1Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan.
International Forum of Allergy & Rhinology
|August 29, 2025
Abstract
Key Points:
Elezanumab accelerates olfactory sensory neuron regeneration in a methimazole-induced mouse model. Repulsive guidance molecule A blockade increases GAP43+ and OMP+ cells dorsally while sparing basal cells. This approach offers a novel therapy for sensorineural olfactory disorder.
Keywords:
axonal regenerationelezanumabneuroepithelial regenerationolfactory sensory neuronsregeneration promotion
