Related Experiment Video
Updated: Sep 9, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Prevalence and Clinical Correlates of Sleep Disorders in RFC1-Spectrum Disorders: A Cross-Sectional Study
Antonio Funcis1, Valerio Brunetti1,2, Salvatore Rossi1
1Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
Patients with RFC1-spectrum disorders experience high rates of sleep disturbances, including obstructive sleep apnea and restless legs syndrome, significantly impacting their quality of life. Early screening for these sleep issues is recommended.
Area of Science:
- Neurology
- Sleep Medicine
- Genetics
Background:
- Sleep disturbances are largely uncharacterized in RFC1-spectrum disorders.
- This study addresses the unmet need to understand sleep issues in this patient population.
Purpose of the Study:
- To determine the prevalence and characteristics of sleep disorders in RFC1-spectrum disorders.
- To assess the impact of these sleep disorders on patients' quality of life.
Main Methods:
- A cohort of 16 patients with RFC1-spectrum disorders underwent comprehensive sleep assessments.
- Methods included validated questionnaires, polysomnography, and quality of life evaluations.
Main Results:
- A high prevalence of sleep disorders was observed: 94% had obstructive sleep apnea, 75% had restless legs syndrome, and 63% had periodic limb movements during sleep.
- Reduced slow-wave and REM sleep correlated with increased clinical severity. All patients reported reduced quality of life.
Conclusions:
- RFC1-spectrum disorders are strongly associated with a high incidence of sleep disorders and diminished quality of life.
- Routine screening for sleep disorders is crucial for managing patients with RFC1-spectrum disorders.
More Related Videos
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
05:59Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
Related Concept Videos
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
REM Sleep Behavior Disorder
RBD is significantly associated with...
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Nightmares and Night Terrors
Nightmares...
Other Pulmonary Disorders
Social Anxiety Disorder