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Updated: Sep 9, 2025
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Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
Published on: July 20, 2016
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Multicomponent reactions (MCRs): an emerging toolbox for protein bioconjugation
Joydip Chatterjee1, Justin R Walensky1, Sayantan Kundu2
1Department of Chemistry, University of Missouri, Columbia, MO 65211, USA.
Organic & Biomolecular Chemistry
|August 29, 2025
Summary
This review details protein bioconjugation using multicomponent reactions (MCRs), highlighting their mechanisms and applications. It explores MCRs for creating versatile bioconjugates in medicine and materials science.
Area of Science:
- Biochemistry
- Materials Science
- Medicinal Chemistry
Background:
- Protein bioconjugation is crucial for developing advanced materials and therapeutics.
- Multicomponent reactions (MCRs) offer efficient methods for creating complex protein bioconjugates.
- A systematic review of MCRs in protein bioconjugation is needed.
Purpose of the Study:
- To review the methodological advancements in protein bioconjugation using MCRs.
- To elucidate the postulated mechanisms of MCRs in bioconjugation.
- To highlight future opportunities in analytical and medicinal chemistry.
Main Methods:
- Literature review of MCRs applied to protein bioconjugation.
- Analysis of reaction mechanisms.
- Identification of applications in various scientific fields.
Main Results:
- Several MCRs have been successfully employed for protein bioconjugation.
- The review details diverse MCR strategies and their underlying mechanisms.
- Significant potential exists for MCR-derived bioconjugates in diagnostics and therapeutics.
Conclusions:
- MCRs represent a powerful and versatile tool for protein bioconjugation.
- Further exploration of MCRs can drive innovation in drug delivery, vaccines, and diagnostics.
- This review provides a comprehensive overview and roadmap for future research.
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