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Niosome-based delivery systems for olanzapine: Formulation, characterisation, and kinetic evaluation
Samiah Alhabardi1, Basmah Aldosari1, Gadah Al-Hamoud2
11Department of Pharmaceutics College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Acta Pharmaceutica (Zagreb, Croatia)
|August 29, 2025
Summary
Niosomes, a novel drug delivery system, were developed for olanzapine, an antipsychotic. Span 60-based niosomes demonstrated optimal characteristics, suggesting improved olanzapine delivery and therapeutic efficacy for psychiatric disorders.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Olanzapine is an essential antipsychotic medication for treating psychiatric disorders.
- Current olanzapine formulations may face challenges with bioavailability and sustained release.
- Niosomes offer a promising nanocarrier system for drug delivery applications.
Purpose of the Study:
- To develop and characterize niosome-based delivery systems for olanzapine.
- To evaluate the impact of surfactant type and cholesterol ratio on niosome properties.
- To assess the in vitro release profile and stability of olanzapine-loaded niosomes.
Main Methods:
- Niosomes were prepared using Span surfactants (Span 60, 40, 20) and cholesterol.
- Formulations were characterized for particle size, PDI, zeta potential, and encapsulation efficiency.
- In vitro drug release studies and kinetic analysis (Korsmeyer-Peppas model) were performed.
Main Results:
- Niosome size was inversely related to surfactant HLB; Span 60 yielded the smallest vesicles.
- Optimal formulations utilized a 1:1 surfactant to cholesterol ratio.
- Span 60 niosomes showed high encapsulation efficiency (81 ± 2.5%) and superior stability.
- All niosomal formulations exhibited sustained olanzapine release compared to the free drug.
Conclusions:
- Niosomal formulations, especially those with Span 60, represent a promising strategy for enhancing olanzapine delivery.
- These niosomes may improve olanzapine bioavailability and therapeutic outcomes in psychiatric disorder treatment.
- The study highlights the potential of niosomes for developing advanced antipsychotic drug delivery systems.
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