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Updated: Sep 9, 2025

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
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Whole-body MRI in arthritis.

Fabio Zecca1,2,3, Denise Dejua1, Winston J Rennie2

  • 1Department of Radiology, University Hospital of Cagliari, Cagliari, Italy.

Skeletal Radiology
|August 29, 2025
PubMed
Summary

Whole-body MRI (wbMRI) offers comprehensive imaging for systemic inflammatory arthritis, detecting subclinical disease better than other methods. Further research is needed to standardize protocols and confirm cost-effectiveness for clinical use.

Keywords:
Inflammatory arthritisJuvenile idiopathic arthritisRheumatoid arthritisSpondyloarthropathyWhole-body imaging

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Area of Science:

  • Radiology and Imaging
  • Rheumatology
  • Medical Technology

Background:

  • Whole-body MRI (wbMRI) provides high-resolution, full-body imaging, increasingly used for systemic conditions.
  • Its comprehensive coverage is valuable for diagnosing and monitoring systemic arthritides, which often involve multiple sites.

Purpose of the Study:

  • To overview current wbMRI technology for inflammatory arthritis.
  • To discuss wbMRI's role in diagnosing and monitoring multifocal inflammatory conditions.
  • To provide a general wbMRI protocol for non-oncologic musculoskeletal applications.

Main Methods:

  • Review of current wbMRI technology and applications in inflammatory arthritis.
  • Comparison of wbMRI sensitivity and reproducibility against radiography, ultrasound, and targeted MRI.
  • Discussion of customizable scan protocols and benefits for monitoring autoimmune diseases.

Main Results:

  • wbMRI enables early detection of subclinical disease foci, offering a more accurate assessment of total disease burden.
  • wbMRI demonstrates superior sensitivity and reproducibility compared to conventional methods, especially for intraosseous and axial involvement.
  • The technology is advantageous for monitoring autoimmune diseases due to its comprehensive nature and lack of ionizing radiation.

Conclusions:

  • wbMRI is a valuable tool for diagnosing and monitoring systemic inflammatory arthropathies.
  • Further research is required to validate standard protocols, assess cost-effectiveness, and integrate wbMRI into routine clinical practice.
  • wbMRI holds significant potential for improving diagnostic accuracy and patient outcomes in inflammatory arthritis.