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Bibliometrics in thyroid eye disease.

YuanPing Hai1,2, QinTao Ma1, Anqi Huang1

  • 1Department of Endocrinology and Metabolism, The Eighth Affiliated Hospital of Southern Medical University, The First People's Hospital of Shunde Foshan, No.1 of Jiazi Road, Lunjiao, Shunde District, Foshan, Guangdong, 528308, China.

Journal of Endocrinological Investigation
|August 29, 2025
PubMed
Summary

This bibliometric analysis maps the research landscape of Thyroid Eye Disease (TED), revealing key focus areas and emerging trends in this common autoimmune disorder.

Keywords:
Artificial intelligenceBibliometricsCiteSpaceResearch hotspotsThyroid eye diseaseVOSviewer

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Area of Science:

  • Ophthalmology and Endocrinology
  • Autoimmune inflammatory disorders
  • Bibliometric analysis of scientific literature

Background:

  • Thyroid Eye Disease (TED) is the most common thyroid-related autoimmune inflammatory disorder.
  • Recent years have seen a significant increase in TED publications, yet a systematic bibliometric analysis was lacking.
  • Understanding the research landscape is crucial for advancing the field.

Purpose of the Study:

  • To systematically map the knowledge structure of Thyroid Eye Disease (TED) research.
  • To identify current research hotspots and emerging trends in TED.
  • To provide a comprehensive overview for researchers in the field.

Main Methods:

  • Bibliometric analysis of publications from 2004-2024 retrieved from Web of Science Core Collection.
  • Utilized VOSviewer, CiteSpace, and R package "Bibliometrix" for data analysis.
  • Included 4,306 publications from 91 countries.

Main Results:

  • Consistent upward trend in TED publications, led by the United States and China.
  • Key research areas include pathogenesis, immunity, treatment, and epidemiology.
  • Emerging hotspots include artificial intelligence, teprotumumab, dysthyroid optic neuropathy, and MRI.

Conclusions:

  • This study is the first comprehensive bibliometric analysis of Thyroid Eye Disease (TED).
  • It summarizes the knowledge mapping, research hotspots, and frontiers of TED.
  • Offers valuable insights for future research directions in the field.