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Updated: Sep 9, 2025

Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle

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Published on: December 1, 2023

Mitochondrial Biogenesis in Skeletal Muscle.

David A Hood¹, Jonathan M Memme², Ashley N Oliveira²

¹Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, ON, Canada. dhood@yorku.ca.

Advances in Experimental Medicine and Biology

|August 29, 2025

Summary

Mitochondrial biogenesis in skeletal muscle involves synthesizing proteins and phospholipids to expand the mitochondrial network. This process is crucial for adapting to exercise, cold, and starvation, with age impacting its signaling.

Keywords:

Aging Calcium Exercise signaling Exercise training Gene expression Mitochondria Mitochondrial dynamics Muscle disuse Protein import ROS

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Last Updated: Sep 9, 2025

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Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria

Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria

Published on: January 7, 2022

Area of Science:

Physiology
Cell Biology
Skeletal Muscle Biology

Background:

Mitochondria form a reticulum in skeletal muscle, optimizing substrate diffusion and metabolic function.
Mitochondria are key responders to metabolic homeostasis disruptions from stimuli like exercise, cold, and starvation.
Skeletal muscle mitochondrial adaptability is central to tissue function and response to external demands.

Purpose of the Study:

To introduce the subcellular events driving mitochondrial biogenesis in skeletal muscle.
To explore mitochondrial content, subpopulations, signaling cascades, and regulatory elements involved.
To review age-related changes in signaling pathways that regulate mitochondrial biogenesis.

Main Methods:

Utilizing models of exercise and muscle disuse to characterize mitochondrial biogenesis.
Incorporating genetic modifications of key regulatory elements in study models.
Reviewing existing literature on mitochondrial biogenesis and its regulation.

Main Results:

Mitochondrial biogenesis is essential for skeletal muscle adaptation to various physiological stressors.
Signaling pathways and regulatory elements significantly influence mitochondrial content and function.
Age-related alterations in signaling impact the capacity for mitochondrial biogenesis.

Conclusions:

Mitochondrial biogenesis is a dynamic process critical for skeletal muscle's metabolic flexibility.
Understanding the regulation of mitochondrial biogenesis provides insights into muscle health and aging.
Targeting mitochondrial biogenesis pathways holds potential for therapeutic interventions in muscle disorders.