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Satellite Stem Cells and Muscular Dystrophy

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Related Experiment Video

Updated: Sep 9, 2025

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

Muscular Dystrophies.

Yi-Wen Chen^1,2, Adam J Bittel³, Daniel C Bittel³

¹Center for Genetic Medicine Research, Children's National Research Institute, Washington, DC, USA. YChen@childrensnational.org.

Advances in Experimental Medicine and Biology

|August 29, 2025

Summary

This summary is machine-generated.

Skeletal muscle disorders disrupt homeostasis, leading to degeneration and impaired regeneration. This chapter reviews common muscular dystrophies, their causes, mechanisms, and emerging therapies.

Keywords:

Atrophy Degeneration Dystrophy Myopathy Regeneration

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Last Updated: Sep 9, 2025

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

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Published on: January 31, 2013

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

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Immunolabelling Myofiber Degeneration in Muscle Biopsies

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

Area of Science:

Muscle biology and regenerative medicine.
Pathology of neuromuscular disorders.

Background:

Skeletal muscles possess remarkable regenerative capacity.
Disruptions in molecular and cellular pathways impair muscle homeostasis.
Muscular dystrophies involve progressive muscle degeneration and regeneration failure.

Purpose of the Study:

To review genetic causes of muscular dystrophies.
To elucidate disease mechanisms in muscular dystrophies.
To discuss therapeutic developments for muscular dystrophies.

Main Methods:

Review of genetic causes.
Analysis of molecular and cellular disease mechanisms.
Survey of current and developing therapeutic strategies.

Main Results:

Identified genetic underpinnings of common muscular dystrophies.
Detailed molecular and cellular pathways involved in disease progression.
Outlined a landscape of therapeutic interventions.

Conclusions:

Muscular dystrophies result from complex genetic and molecular defects.
Regeneration failure is a key factor in muscle loss.
Therapeutic development offers hope for managing these progressive diseases.