Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

12.4K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
12.4K
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

89.6K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
89.6K
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

13.4K
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
13.4K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.1K
Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

15.0K
Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
15.0K
The Muscular System01:18

The Muscular System

4.8K
The muscular system is essential to the body's overall structure and function, playing a crucial role in movement, stability, and internal processes. It consists of three distinct types of muscle tissue: the skeletal, the smooth, and the cardiac muscles.
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1.

bioRxiv : the preprint server for biology·2026
Same author

The gut microbiome enhances breast cancer immunotherapy following bariatric surgery.

JCI insight·2025
Same author

Polysaccharides with Arabinose: Key Players in Reducing Chronic Inflammation and Enhancing Immune Health in Aging.

Molecules (Basel, Switzerland)·2025
Same author

Modulatory Effects of Mdivi-1 on OxLDL-Induced Metabolic Alterations, Inflammatory Responses, and Foam Cell Formation in Human Monocytes.

bioRxiv : the preprint server for biology·2025
Same author

Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism.

International journal of molecular sciences·2024
Same author

Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages.

Exploration of immunology·2024

Related Experiment Video

Updated: Sep 9, 2025

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
08:35

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells

Published on: June 12, 2017

10.3K

Skeletal Muscle and the Immune System.

Brandt D Pence1

  • 1College of Health Sciences, University of Memphis, Memphis, TN, USA. bdpence@memphis.edu.

Advances in Experimental Medicine and Biology
|August 29, 2025
PubMed
Summary

The immune system protects the body, and its interaction with skeletal muscle is crucial for repair, adaptation, and exercise benefits. Further research is needed to fully understand this relationship.

Area of Science:

  • Immunology
  • Skeletal Muscle Physiology

Background:

  • The mammalian immune system comprises innate and adaptive responses for host defense and tissue repair.
  • Immune cells play vital roles in skeletal muscle functions like damage repair, satellite cell activity, and adaptation to exercise and pathology.
  • Skeletal muscle serves as a vaccination site and produces immune-modulating substances, particularly relevant to physical exercise benefits.

Purpose of the Study:

  • To explore the fundamental aspects of immunology.
  • To detail the specific roles of the immune system within skeletal muscle.
  • To highlight the known and unknown interactions between immunity and skeletal muscle.

Main Methods:

  • Review of existing literature on immunology and skeletal muscle physiology.
Keywords:
Immune systemInflammationLeukocytesMyokinesVaccination

More Related Videos

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

22.3K
Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

40.7K

Related Experiment Videos

Last Updated: Sep 9, 2025

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
08:35

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells

Published on: June 12, 2017

10.3K
Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

22.3K
Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

40.7K
  • Focus on the functions of immune cells in skeletal muscle.
  • Examination of skeletal muscle's role in immune responses and its production of immunomodulatory factors.

    • Main Results:

    • Immune cells are integral to skeletal muscle adaptation, repair, and response to stimuli like exercise.
    • Skeletal muscle's vascularity and location make it suitable for vaccination.
    • Skeletal muscle releases factors that influence immune function locally and systemically, potentially explaining exercise's immune benefits.

    Conclusions:

    • Immune cells are critical regulators of skeletal muscle homeostasis and adaptation.
    • Skeletal muscle actively participates in systemic immune modulation, notably linked to physical activity.
    • Despite significant knowledge in both fields, the intricate relationship between the immune system and skeletal muscle remains underexplored.