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Developing an EQ-5D-5L Value Set for Singapore.

Nan Luo1, Annushiah Vasan Thakumar2, Ling Jie Cheng3,4,5

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A new EQ-5D-5L value set for Singapore was developed using the composite time trade-off method. This tool reflects Singaporean health preferences, ranging from -0.851 to 1.000.

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Area of Science:

  • Health Economics
  • Psychometrics
  • Quality of Life Research

Background:

  • The EQ-5D-5L is a widely used multi-attribute utility instrument for health technology assessment.
  • Developing region-specific value sets is crucial for accurate health outcome valuation.

Purpose of the Study:

  • To develop an EQ-5D-5L value set tailored to the Singaporean population.
  • To provide a standardized tool for health valuation in Singapore.

Main Methods:

  • A 'lite' version of the EuroQol Research Foundation's valuation protocol was employed.
  • Composite time trade-off (cTTO) tasks were administered to 500 quota-sampled Singapore residents.
  • Cross-validation identified the optimal model for valuing all 3,125 EQ-5D-5L health states.

Main Results:

  • A 20-parameter main-effects model with two two-way interaction terms demonstrated superior performance.
  • The resulting value set spans from -0.851 (worst health state) to 1.000 (best health state).
  • The pain/discomfort and anxiety/depression dimensions contributed most significantly to disutility.

Conclusions:

  • A novel EQ-5D-5L value set for Singapore has been successfully developed.
  • This value set is recommended for use by EQ-5D-5L users in Singapore.
  • Further research into interaction effects and non-linearities in health state valuation is encouraged.