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Related Concept Videos

Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Measuring Fatigue in Multiple Sclerosis: A Rapid Review.

Tergel Namsrai1, Anne Parkinson1, Richard Burns1

  • 1National Centre for Epidemiology and Population Health, The Australian National University, Building 63A, Acton, ACT, 2601, Australia.

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Summary
This summary is machine-generated.

Current multiple sclerosis (MS) fatigue scales miss key aspects of patient experiences. Developing comprehensive tools requires integrating subjective patient data to accurately measure MS-related fatigue triggers, domains, and impacts.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Psychology

Background:

  • Fatigue is a prevalent and debilitating symptom in multiple sclerosis (MS), often preceding clinical diagnosis and indicating disease progression.
  • Accurate measurement of MS-related fatigue is crucial for management and research, yet current tools often lack content validity.
  • Existing fatigue scales may not fully capture the multifaceted nature of fatigue experienced by individuals with MS.

Purpose of the Study:

  • To examine existing literature on MS-related fatigue to define its key aspects.
  • To compare these defined aspects with the content of currently used validated fatigue scales in MS.
  • To identify gaps in measurement tools for MS-related fatigue.

Main Methods:

  • An integrated rapid review (PROSPERO registration: CRD42024505743) synthesized evidence on MS-related fatigue domains and their representation in validated scales.
  • A systematic search of PubMed, Scopus, and ProQuest was conducted, including studies on MS fatigue domains, symptoms, and validated scales.
  • Data synthesis involved meta-aggregation of fatigue aspects and mapping them against items from 29 identified fatigue measurement scales.

Main Results:

  • Eighty-five studies involving 34,984 participants were included, identifying 791 fatigue-related items categorized into triggers, domains, and impacts.
  • Eight fatigue triggers, five domains (general, physical, cognitive, psychosocial, social), and five impact areas were identified.
  • While nineteen validated self-report scales exist, they did not fully capture medical/lifestyle triggers or psychological/global impacts, and no single scale covered all aspects.

Conclusions:

  • Integrating subjective patient experiences is vital for developing comprehensive and meaningful tools to measure multidimensional MS-related fatigue.
  • Improved measurement tools are critical for better understanding fatigue mechanisms, tracking, and management in clinical practice and research.
  • A clearer understanding of fatigue triggers, domains, and impacts is essential for advancing MS care.