Related Experiment Video
Updated: Sep 9, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Reddish/bluish benign lesions evaluated by dermus SkinScanner
Carmen Cantisani1, Phyllida Kerstin Hamilton-Maikle2,3, Mattia Di Segni4
1UOC of Dermatology, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy. carmen.cantisani@uniroma1.it.
Dermoscopy-assisted high-frequency ultrasound (DA-HFUS) aids in distinguishing benign skin lesions like angiomas and blue nevi. This non-invasive imaging technique provides complementary structural information to dermoscopy for accurate diagnosis.
Area of Science:
- Dermatology
- Medical Imaging
- Pathology
Background:
- Angiomas and blue nevi are common benign skin lesions.
- These lesions can clinically resemble malignant conditions like melanoma.
- Accurate differentiation is crucial for appropriate patient management.
Purpose of the Study:
- To evaluate the utility of dermoscopy-assisted high-frequency ultrasound (DA-HFUS) in characterizing angiomas and blue nevi.
- To assess the complementary role of DA-HFUS alongside dermoscopy.
- To improve non-invasive diagnostic capabilities for benign pigmented skin lesions.
Main Methods:
- Case study involving five patients with diagnosed angiomas (2) and blue nevi (3).
- Utilized a handheld 33 MHz Dermus SkinScanner with integrated optical guidance for DA-HFUS.
- Correlated dermoscopic findings with high-frequency ultrasound imaging characteristics.
Main Results:
- Dermoscopy showed blue nevi as regular, slate blue/brown lesions and angiomas as blue-purple papules with lacunes.
- Ultrasound revealed blue nevi as hypoechoic lesions with potential hyperechoic fibrotic foci.
- Angiomas displayed heterogeneous echotexture reflecting vascular and fibrous components; fibrotic blue nevi showed deep dermal extensions.
- DA-HFUS identified structural details, such as hyperechogenic columns in fibrotic blue nevi, not visible on dermoscopy.
Conclusions:
- DA-HFUS provides valuable complementary information to dermoscopy for characterizing benign pigmented lesions.
- The combined approach enhances non-invasive diagnostic accuracy for differentiating angiomas and blue nevi.
- DA-HFUS aids in the structural assessment of these common skin lesions, potentially reducing misdiagnosis.
More Related Videos
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

