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Dried Blood Spot PCR for Detection of Congenital Cytomegalovirus Infection and Disease

Mark R Schleiss1, Erin A Osterholm2, Ryan Shanley3

  • 1Division of Pediatric Infectious Diseases and Immunology, Center for Infectious Diseases and Microbiology Translational Research, Minneapolis, Minnesota.

JAMA Network Open
|August 29, 2025
PubMed
Abstract

No abstract available in PubMed .

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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
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