Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.1K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.1K
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

297
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
297
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

27
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
27
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

57
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
57
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

37
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
37
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

711
Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
711

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glial neurovascular unit protein dysregulation and risk of idiopathic intracranial hypertension: A systematic review and meta-analysis.

German medical science : GMS e-journal·2026
Same author

TBC1D2B-related Neurodevelopmental Disorder with Gingival Overgrowth and Movement Disorders: A Case Series and Literature Review.

Journal of movement disorders·2026
Same author

Clinical and Genetic Characteristics of SCA27B: A Global Systematic Review and Meta-Analysis.

Cerebellum (London, England)·2026
Same author

Genetic modifiers of Friedreich's ataxia pathophysiology in Drosophila melanogaster - A systematic review and meta-analysis.

Free radical biology & medicine·2026
Same author

Deep brain stimulation of the globus pallidus internus in FBXO7-related parkinsonism-dystonia.

Parkinsonism & related disorders·2026
Same author

Reply to "The role of early immunotherapy in Rasmussen's encephalitis".

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Related Experiment Video

Updated: Sep 9, 2025

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

1.5K

Diffusion Restriction in Wilson's Disease: A Radiological Pointer Toward Clinically Severe Disease.

Divyani Garg1, Shariq Ahmad Shah2, Ayush Agarwal1

  • 1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Annals of Indian Academy of Neurology
|August 29, 2025
PubMed
Summary

Diffusion restriction on MRI may indicate more severe Wilson's disease (WD), affecting the brain and liver. Patients with diffusion restriction require closer monitoring for neurological and hepatic complications.

Keywords:
Copperapparent diffusion coefficientdiffusion-weighted imagingglobal assessment scale for Wilson’s diseasemagnetic resonance imaging

More Related Videos

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.6K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.2K

Related Experiment Videos

Last Updated: Sep 9, 2025

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

1.5K
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.6K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.2K

Area of Science:

  • Neurology
  • Hepatology
  • Radiology

Background:

  • Wilson's disease (WD) is an inherited disorder of copper metabolism.
  • Abnormal copper transport leads to accumulation in organs like the liver and brain.
  • Conventional MRI is useful, but diffusion-weighted imaging (DWI) in WD is less understood.

Purpose of the Study:

  • To determine the frequency of diffusion restriction in Wilson's disease patients.
  • To identify clinical factors associated with diffusion restriction on MRI.

Main Methods:

  • Retrospective analysis of 91 Wilson's disease patients.
  • Patients were diagnosed using a modified Leipzig score.
  • Comparison of clinical and MRI data between groups with (WDDR+) and without (WDDR-) diffusion restriction.

Main Results:

  • 18.7% of WD patients showed diffusion restriction (WDDR+).
  • WDDR+ patients had earlier symptom onset, higher Leipzig scores, and worse Global Assessment Scale scores.
  • WDDR+ group had increased rates of dysphagia, portal hypertension, and early neurological deterioration.

Conclusions:

  • Diffusion restriction on MRI may signify more severe neurological and hepatic involvement in WD.
  • This finding suggests a need for heightened surveillance in WD patients with diffusion restriction.