Related Experiment Video
Updated: Sep 9, 2025
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
Motivation, barriers, and willingness to participate in clinical trials for novel cancer treatments among the
Pol Van Nguyen1, Thanh Thi Thuy Tran1, Hieu Thi Thanh Nguyen2
1Faculty of Pharmacy, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
Background:
Novel therapeutic approaches are actively explored and evaluated, but applying these innovations to practice depends critically on the recruitment of volunteers for clinical trials. This study aimed to assess the motivations, barriers, and willingness of the general population in Vietnam to participate in clinical trials for novel cancer treatments.
Methods:
This analytical cross-sectional research involved the distribution of self-administered online and printed questionnaires to residents across central and southern Vietnam in December 2024. A structured 23-item questionnaire was developed based on a literature review of studies from the UK, US, and Germany. Items were culturally adapted for Vietnam and translated using a WHO-adapted four-step process, including forward translation, expert panel review, cognitive interviews with 25 participants, and final revision. Face and content validity were assessed during this process. Logistic regression analysis was conducted to determine the factors associated with the respondents' willingness to participate in the aforementioned clinical trials.
Results:
The questionnaires were completed by 851 participants, with the majority aged 40-50 years (30.3%). The respondents also indicated a preference for treatments with prior clinical use and coverage by health insurance (65.6%). The primary motivation for participation was intensive monitoring of conditions (83.7%). The most frequently cited barrier were concerns regarding the high risk associated with less-tested treatments (74.1%). A total of 33.6% expressed a willingness to participate in clinical trials, but fewer (18.9%) were willing to allow such involvement for their children or other family members. Finally, Kinh ethnicity, good health, and positive attitudes toward novel cancer treatments were significantly associated with an increased willingness to participate in clinical trials (p < 0.05).
Conclusion:
This study provides critical insights into the motivation of and barriers to participation in clinical trials for novel cancer treatments. Addressing barriers and promoting motivations can contribute to supporting cancer clinical trial conductions and then improving cancer treatment effectiveness in Vietnam.
Insights
Most Vietnamese adults are motivated to join cancer clinical trials for intensive monitoring, but fear of high-risk treatments is a major barrier. Addressing these concerns is key to improving cancer treatment research in Vietnam.
Area of Science:
- Oncology
- Clinical Trials
- Public Health
Background:
- Clinical trial participation is crucial for advancing novel cancer therapies.
- Understanding public willingness is essential for successful recruitment in Vietnam.
Purpose of the Study:
- To assess motivations, barriers, and willingness to participate in novel cancer treatment clinical trials among the Vietnamese population.
- To identify factors influencing participation in cancer clinical trials in Vietnam.
Main Methods:
- Cross-sectional study using online and printed questionnaires distributed in central and southern Vietnam.
- Culturally adapted 23-item questionnaire developed and validated using WHO guidelines.
- Logistic regression analysis to identify factors associated with willingness to participate.
Main Results:
- 851 participants completed the survey; 33.6% expressed willingness to join clinical trials.
- Primary motivation: intensive monitoring (83.7%). Primary barrier: high risk of novel treatments (74.1%).
- Kinh ethnicity, good health, and positive attitudes toward novel treatments were associated with higher willingness.
Conclusions:
- Insights into motivations and barriers for cancer clinical trial participation in Vietnam are provided.
- Addressing participant concerns and promoting trial benefits can enhance recruitment.
- Improving clinical trial participation can advance cancer treatment effectiveness in Vietnam.
More Related Videos
14:43A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
Related Concept Videos
01:11Clinical Trials: Overview
01:16Clinical Trials
There are four phases in a clinical trial. A phase one...
02:56Treatment Resistant Cancers
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
01:27Nursing Ethical Principles II
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...