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Updated: Sep 9, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Informational Polymers with Precise Carbamate Sequences
Itab Youssef1,2, Svetlana Samokhvalova1,2, Isaure Sergent3
1Université de Strasbourg, CNRS, ISIS, 8 allée Gaspard Monge, 67000 Strasbourg, France.
Abstract:
Sequence-defined oligocarbamates were synthesized by orthogonal iterative chemistry on a modified Wang solid support. In this approach, amino alcohol building blocks, containing either primary or secondary amines, were used in order to obtain on-demand either a classical urethane motif -NH-CO-O- or a N-substituted urethane linkage -NR-CO-O-. Hence, aperiodic carbamate sequences could be easily prepared in this work. Polymers with different monomer sequences and chain-length were synthesized. Characterization by NMR, SEC and ESI-MS indicated formation of near-monodisperse polymers. Furthermore, these informational oligocarbamates were sequenced by MS/MS. Very interestingly, it was found that a fully orthogonal fragmentation of -NH-CO-O- urethane motifs occurs in these macromolecules.
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