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A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

Published on: February 5, 2016

Atomically Precise Water-Soluble Gold Nanoclusters: Synthesis and Biomedical Application.

Qian Yan¹, Zhaotong Yuan¹, Yating Wu¹

¹Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

Precision Chemistry

|August 29, 2025

Summary

Atomically precise gold nanoclusters (Au NCs) show promise for theranostic applications due to their unique properties. This review details their synthesis and biomedical uses, including imaging, sensing, and therapy.

Keywords:

Gold nanocluster biodiagnostic theranostic water-soluble well-defined structure

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Last Updated: Jun 3, 2026

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Gold Nanoparticle Synthesis

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Published on: July 10, 2021

Area of Science:

Nanomaterials Science
Biomedical Engineering
Chemistry

Background:

Water-soluble gold nanoclusters (Au NCs) are emerging as versatile nanomaterials.
Their ultrasmall size, photoluminescence, biocompatibility, and low toxicity are advantageous.
Au NCs offer well-defined atomic structures for studying structure-performance relationships.

Purpose of the Study:

To review the synthesis of water-soluble Au NCs.
To summarize recent advancements in biomedical applications of Au NCs.
To discuss the influence of ligand and size on biomedical properties.

Main Methods:

Literature review focusing on synthesis and biomedical applications of Au NCs.
Analysis of structure-performance correlations in biodistribution, pharmacokinetics, and excretion.
Detailed examination of ligand and size effects on biomedical properties.

Main Results:

Gold nanoclusters demonstrate significant potential in bioimaging, biosensing, and biotherapy.
Ligand choice and cluster size critically influence biodistribution and pharmacokinetic profiles.
Well-defined atomic structures facilitate understanding of in vivo behavior.

Conclusions:

Water-soluble Au NCs are promising theranostic tools.
Further research into ligand and size optimization can enhance their biomedical utility.
Advances in Au NCs are expected to expand their clinical applications.