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Updated: May 5, 2026
A Microfluidic Technique to Probe Cell Deformability
Published on: September 3, 2014
High throughput cell mechanotyping of cell response to cytoskeletal modulations using a microfluidic cell deformation
Ian M Smith1, Jeanine A Ursitti2, Sai Pranav Majeti Venkata1
1Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
None:
Cellular mechanical properties influence cellular functions across pathological and physiological systems. The observation of these mechanical properties is limited in part by methods with a low throughput of acquisition or with low accessibility. To overcome these limitations, we have designed, developed, validated, and optimized a microfluidic cellular deformation system (MCDS) capable of mechanotyping suspended cells on a population level at a high throughput rate of ~300 cells per second. The MCDS provides researchers with a viable method for efficiently quantifying cellular mechanical properties towards defining prognostic implications of mechanical changes in pathology or screening drugs to modulate cytoskeletal integrity.
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