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From collection to correction: Can serial 24-hour urine collections demonstrate improved urinary stone parameters?
Daniel Jhang1, Jason Groegler1, Akin S Amasyali1
1Department of Urology Loma Linda University Health Loma Linda CA USA.
BJUI Compass
|August 29, 2025
Summary
Serial 24-hour urine collections can improve kidney stone risk parameters. Repeat testing, especially at 6-month intervals, aids in correcting urinary stone indicators for active stone formers.
Area of Science:
- Nephrology
- Urology
- Biochemistry
Background:
- Kidney stone formation is influenced by various urinary parameters.
- Monitoring these parameters is crucial for effective stone management.
- Serial testing offers a longitudinal view of patient risk factors.
Purpose of the Study:
- To evaluate if repeated 24-hour urine collections improve the assessment of kidney stone risk parameters.
- To determine the impact of serial urine testing on urinary composition over time.
Main Methods:
- Retrospective review of 1832 24-hour urine tests from 688 patients over 10 years.
- Inclusion criteria: minimum 2-year follow-up and at least three urine collections.
- Statistical analysis using repeated measures ANOVA and post-hoc tests.
Main Results:
- 225 patients met the criteria for analysis.
- Significant improvements in volume and supersaturation of calcium oxalate (CaOx), calcium phosphate (CaP), and uric acid (UA) from the first to the second collection.
- Further significant improvement in CaP supersaturation from the second to the third collection.
Conclusions:
- Serial 24-hour urine collections, particularly at intervals of 6 months or more, are linked to improved stone risk parameters.
- This method can assist in correcting urinary stone parameters.
- Serial urine testing is recommended for patients with active stone formation.
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