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Applications of Aggregation-Induced Emission Materials in Immunology: From Diagnostics to Immunotherapy

Langyi Yang1, Ling-Hong Xiong2, Xuewen He1

  • 1State Key Laboratory of Bioinspired Interfacial Materials Science, The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

Chemical & Biomedical Imaging
|August 29, 2025
PubMed

Aggregation-induced emission (AIE) materials, due to their unique ability to significantly enhance optical emission in aggregated states, have demonstrated vast potential in immunology, particularly in early disease diagnosis and immunotherapy. AIE materials can serve as highly efficient fluorescent probes for biomarker detection, providing critical insights for early diagnosis. Additionally, they can act as cancer vaccines, enhancing the effectiveness of immunotherapy through photodynamic therapy, photothermal therapy, or activation of immune cells. This review highlights the applications of AIE materials in immunology, focusing on recent advancements in disease immune diagnostics and immunotherapy while also discussing the challenges they face and potential directions for future development.

Keywords:
Aggregation-induced emissionDiagnosticsImmunotherapyPhotodynamic therapyPhotothermal therapy

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