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Primary Jejunal Angiosarcoma.
Michelle Mai1, Sapana Gupta2, Kanhai Farrakhan2
1Warren Alpert Medical School of Brown University, Providence, RI.
ACG Case Reports Journal
|August 29, 2025
Summary
Primary jejunal angiosarcoma is a rare cancer. Early diagnosis and surgery did not prevent metastasis, suggesting a need for earlier systemic therapy in localized cases.
Area of Science:
- Oncology
- Gastroenterology
- Soft-tissue neoplasm research
Background:
- Primary jejunal angiosarcoma is a rare, aggressive soft-tissue neoplasm with a poor prognosis.
- Diagnosis typically involves endoscopic intervention, radiographic imaging, and immunohistochemistry.
- Limited cases (62) reported, with most presenting with distant metastases.
Observation:
- A 51-year-old male presented with melena and a jejunal mass.
- Initial staging revealed angiosarcoma without metastases.
- Diagnosis confirmed via histomorphology and immunohistochemistry.
Findings:
- Despite early staging and successful surgical resection, the patient developed metastatic disease 6 months post-surgery.
- This case underscores the aggressive nature of jejunal angiosarcoma.
Implications:
- Highlights the need for comprehensive diagnostic strategies in small bowel tumors.
- Suggests considering earlier systemic or neoadjuvant therapy for early-stage jejunal angiosarcoma.
- Emphasizes the potential for aggressive behavior even in localized disease.
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