Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Differential Fibrocartilage Degradation Between Sexes in a Burn-Synovectomy Temporomandibular Osteoarthritis Mouse Model.

Orthodontics & craniofacial research·2025
Same author

A Novel Burn / Synovectomy Mouse Model for Temporomandibular Joint Osteoarthritis.

bioRxiv : the preprint server for biology·2023
Same author

Differential pericyte marker expression in craniofacial benign and malignant vascular tumors.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2023
Same author

ZIC1 Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism.

Stem cells (Dayton, Ohio)·2023
Same author

TIAM1 acts as an actin organization regulator to control adipose tissue-derived pericyte cell fate.

JCI insight·2023
Same author

Acetabular Reaming Is a Reliable Model to Produce and Characterize Periarticular Heterotopic Ossification of the Hip.

Stem cells translational medicine·2022

Related Experiment Video

Updated: Jul 2, 2026

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
09:26

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

Published on: May 16, 2016

35.7K

BURN-SYNOVECTOMY MOUSE MODEL FOR TEMPOROMANDIBULAR JOINT OSTEOARTHRITIS.

Ginny Ching-Yun Hsu1

  • 1Department of Orthodontics, Oregon Health & Science University, Portland, OR 97201, USA.

European Cells & Materials
|August 29, 2025
PubMed
Summary
This summary is machine-generated.

A new mouse model effectively simulates temporomandibular joint osteoarthritis (TMJ OA) by combining local trauma and systemic inflammation. This model accurately mimics disease progression, aiding future TMJ OA research.

Keywords:
Temporomandibular joint osteoarthritismouse modeltemporomandibular disorders

More Related Videos

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.4K
Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
06:37

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

1.1K

Related Experiment Videos

Last Updated: Jul 2, 2026

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
09:26

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

Published on: May 16, 2016

35.7K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.4K
Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
06:37

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

1.1K

Area of Science:

  • Biomedical research
  • Osteoarthritis modeling
  • Animal models

Background:

  • Temporomandibular joint osteoarthritis (TMJ OA) affects 8-16% of the population.
  • Existing animal models fail to replicate TMJ OA's natural disease course.
  • TMJ OA development necessitates both local injury and sustained inflammation.

Purpose of the Study:

  • To develop and validate a novel mouse model for TMJ OA.
  • To reproduce the key etiological factors of TMJ OA: local trauma and systemic inflammation.
  • To provide a reliable platform for investigating TMJ OA mechanisms and risk factors.

Main Methods:

  • A novel procedure combining synovectomy (local trauma) and distant burn injury (systemic inflammation) was performed on mice.
  • Histomorphologic and radiographic evaluations assessed TMJ changes at 1, 3, and 9 weeks post-procedure.
  • Comparison between burn-synovectomy, synovotomy-only, and control groups.

Main Results:

  • Burn-synovectomy mice showed significantly greater degenerative changes in TMJ hard and soft tissues compared to controls.
  • Histological findings in the burn-synovectomy group closely resembled synovitis-induced TMJ OA.
  • The model successfully induced TMJ OA mimicking key pathological features.

Conclusions:

  • The developed burn-synovectomy mouse model accurately replicates TMJ OA.
  • This model is a valuable tool for future research into TMJ OA pathogenesis and risk factors.
  • It offers a more faithful representation of human TMJ OA than previous models.