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Protein lactylation in kidney diseases
Yelei Xu1, Xinming Li1,2, Zhiguo Mao2
1Naval Medical University (Second Military Medical University), Shanghai, China.
Frontiers in Cell and Developmental Biology
|August 29, 2025
Summary
Lysine lactylation, a protein modification from glycolysis by-product lactate, impacts kidney disease progression. Understanding lactylation offers new therapeutic strategies for kidney diseases.
Area of Science:
- Biochemistry
- Molecular Biology
- Epigenetics
Background:
- Post-translational modifications (PTMs) are crucial for protein function and cellular processes.
- Lysine lactylation is an emerging PTM involving the addition of a lactyl group to lysine residues.
- Lactate, a glycolysis by-product, influences cellular metabolism and disease development via lactylation.
Purpose of the Study:
- To review the discovery and regulatory mechanisms of lysine lactylation.
- To explore the specific roles of lactylation in kidney diseases, including acute kidney injury (AKI), chronic kidney disease (CKD), and diabetic kidney disease (DKD).
Main Methods:
- Literature review focusing on recent research in lysine lactylation and kidney diseases.
- Analysis of the molecular mechanisms by which lactylation affects renal cells.
- Synthesis of findings on lactylation's impact on metabolism, inflammation, and fibrosis in the kidney.
Main Results:
- Lysine lactylation modulates protein function and gene transcription in renal cells.
- Lactylation influences the metabolic state, inflammatory response, and fibrosis in kidney disease contexts.
- Emerging evidence links lactylation to the pathogenesis of AKI, CKD, and DKD.
Conclusions:
- Lysine lactylation plays a significant role in the metabolic-epigenetic regulation of kidney diseases.
- Targeting lactylation pathways presents potential novel therapeutic strategies for kidney disease treatment.
Keywords:
acute kidney injurychronic kidney diseasediabetic kidney diseaselactatelactylationpost-translational modificationMore Related Videos
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