JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Clinical features and prognosis of carcinoma ex pleomorphic adenoma of the lacrimal gland: a comprehensive case series and literature review

  • 0Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
International Journal of Ophthalmology +

|

August 29, 2025

|

August 29, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Carcinoma ex pleomorphic adenoma (CXPA) often presents with bone destruction. Surgery combined with 125I radiation therapy improves survival, but long-term monitoring for recurrence is crucial.

Area Of Science

  • Ophthalmology
  • Oncology
  • Pathology

Background

  • Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant tumor arising from a pre-existing pleomorphic adenoma.
  • Understanding its clinical and pathological features is essential for accurate diagnosis and treatment planning.

Purpose Of The Study

  • To analyze the clinical characteristics, pathological types, and treatment outcomes of CXPA.
  • To provide insights for improving the clinical assessment and prognosis of CXPA.

Main Methods

  • Retrospective analysis of clinical data from 26 patients with pathologically diagnosed CXPA.
  • Inclusion of patient demographics, clinical manifestations, pathological and immunohistochemical findings, treatments, and prognosis.
  • Statistical analysis of survival rates based on various factors.

Main Results

  • The average patient age was 59.6 years; gender distribution was even.
  • Bone destruction occurred in 57.7% of cases; optic nerve and extraocular muscle involvement were observed in 15.4% and 19.2%, respectively.
  • Adenocarcinoma was the most common type (34.6%). The 5-year recurrence-free survival rate was 59.0%. Surgery with 125I radiation therapy significantly improved prognosis (P<0.05).

Conclusions

  • CXPA exhibits diverse pathological classifications and frequently involves bone destruction and peripheral tissue invasion.
  • Combined surgery and 125I endoradiotherapy represent a preferred treatment strategy.
  • Close long-term follow-up is necessary to monitor for recurrence or metastasis.

Keywords: