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Updated: Sep 9, 2025

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Clots in colitis: Thromboembolism and beyond.

Hakim Rahmoune^1,2, Nada Boutrid³

¹Department of Medicine, LIRSSEI Research Laboratory, Faculty of Medicine, University of Setif-1, Setif 19000, Algeria.

World Journal of Clinical Cases

|August 29, 2025

Summary

Patients with ulcerative colitis (UC) face a higher risk of venous thromboembolism (VTE). This risk is influenced by inflammation, medications, surgery, and potentially genetics, necessitating effective prevention strategies.

Keywords:

Incidence Risk Surgery Ulcerative colitis Venous thromboembolism

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Area of Science:

Gastroenterology
Hematology
Clinical Medicine

Background:

Ulcerative colitis (UC) patients exhibit elevated risks for thromboembolic events, especially venous thromboembolism (VTE).
VTE incidence in UC is substantially higher compared to the general population, indicating a significant clinical concern.

Discussion:

Colectomy in UC patients presents a notable VTE risk, exacerbated by pre-operative tofacitinib exposure (up to 22%).
The GETAID FOCUS study highlights a pooled VTE prevalence of approximately 12% in UC patients.
Thromboembolism risk in UC is multifactorial, involving chronic inflammation, diverse medications, surgical procedures, and potential genetic predispositions.

Key Insights:

UC is a significant risk factor for VTE, encompassing deep vein thrombosis and pulmonary embolism.
Surgical interventions like colectomy and specific medications (e.g., tofacitinib) can further elevate VTE risk in UC patients.
Understanding the multifactorial nature of VTE in UC is critical for risk assessment and management.

Outlook:

Further research is needed to elucidate genetic factors contributing to VTE in UC.
Developing targeted preventive strategies for VTE in UC patients is essential for improving outcomes.
Enhanced monitoring and risk stratification protocols may reduce thromboembolic event rates in this population.