Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

7.5K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.5K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Cell Migration01:19

Cell Migration

5.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
5.1K
Metastasis02:30

Metastasis

5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.5K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.5K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineered microtissue systems for identifying the roles of Wnt and YAP signaling in hepatoblast differentiation and organization.

Materials today. Bio·2026
Same author

Biomimetic model for the identification of distinctive microenvironmental factors in glioblastoma radiosensitivity.

Clinical and translational radiation oncology·2026
Same author

Reciprocal Macrophage-MSC Crosstalk Drives Immunomodulatory and Regenerative Phenotypes in a Mineralized Collagen Scaffold.

Journal of biomedical materials research. Part A·2026
Same author

A microgel bone marrow model of mesenchymal stromal cell paracrine signaling supporting hematopoietic stem cell retention.

Acta biomaterialia·2026
Same author

Characterising the neuro-oscillatory signatures of spontaneous and deliberate music-evoked visual imagery and examining their role in stress recovery.

Cognitive, affective & behavioral neuroscience·2026
Same author

An interfacial hydrogel compartment within a multicompartment tendon-to-bone scaffold influences cell behavior under cyclic tensile loading.

Regenerative biomaterials·2026

Related Experiment Video

Updated: Sep 9, 2025

High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition
13:34

High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition

Published on: June 1, 2019

9.6K

Matrix Tropism Influences Endometriotic Cell Attachment Patterns.

Hannah S Theriault1,2, Hannah R C Kimmel1,2, Alison C Nunes2

  • 1Dept. of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

Advanced Functional Materials
|August 29, 2025
PubMed
Summary

Researchers explored how ovarian endometriotic lesions begin by studying endometriotic cell attachment to ovarian tissues. They identified specific ovarian tissue features that promote endometriotic cell adhesion, offering insights into early endometriosis development.

Keywords:
Endometriosisextracellular matrixlesion initiationtissue engineering

More Related Videos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.3K
Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry
09:28

Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry

Published on: June 4, 2015

15.7K

Related Experiment Videos

Last Updated: Sep 9, 2025

High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition
13:34

High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition

Published on: June 1, 2019

9.6K
Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.3K
Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry
09:28

Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry

Published on: June 4, 2015

15.7K

Area of Science:

  • Reproductive biology
  • Cell biology
  • Biomaterials science

Background:

  • Endometriosis initiation is poorly understood, often diagnosed late.
  • Endometriotic lesions commonly affect pelvic organs, particularly ovaries.
  • Tissue tropism's role in ovarian endometrioma initiation requires investigation.

Purpose of the Study:

  • To investigate tissue tropism in ovarian endometrioma initiation.
  • To examine extracellular matrix and adhesion motifs' effects on endometriotic cells.
  • To understand how cell origin, substrate stiffness, and multicellularity influence endometriotic cell attachment.

Main Methods:

  • Adapted a polyacrylamide microarray system.
  • Studied endometriotic vs. non-endometriotic cell attachment, morphology, and size.
  • Assessed substrate stiffness mimicking aging and fibrosis.
  • Investigated multicellular epithelial-stromal cohort interactions.

Main Results:

  • Identified ovarian-specific attachment motifs that enhance endometriotic cell attachment.
  • Observed increased attachment of endometriotic cells compared to non-endometriotic cells.
  • Demonstrated the influence of cell origin, substrate stiffness, and multicellularity on attachment patterns.

Conclusions:

  • Ovarian-specific adhesion motifs may play a crucial role in endometriotic lesion initiation.
  • Findings suggest mechanisms for early endometriosis development on ovarian tissues.
  • This research provides a foundation for understanding endometriosis etiology.