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Updated: Sep 9, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
Longitudinal profiling of the human gut microbiome reveals temporal and personalized responses to inulin
Lu Wu1, Hong-Bin Liu1, Xu-Wen Wang2
1CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Abstract:
This study monitored gut microbiome changes in healthy volunteers following inulin intervention, revealing dynamic and highly individualized shifts in microbial composition and short-chain fatty acid production. Using in vitro batch cultures, correlation analysis, and predictive modeling, we explored the personalized microbiome response. Our findings highlight the individualized response of the gut microbiome to prebiotics and the need for precision nutrition.
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