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The levels of miR-155 in epilepsy patients: a meta-analysis
Yi Wang1, Cong Chen2, Chengyu Ya1
1Graduate School of First Clinical Medicine College, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Background:
Neuroinflammation plays an important role in the development and progression of epilepsy. It can be both a result and a potential cause of those seizures. MiR-155 plays a crucial role in inflammatory responses, and its expression is upregulated under various neuroinflammatory conditions. This study aims to compare the expression levels of miR-155 in the brain tissue or serum of epilepsy patients and healthy controls, assessing the correlation between miR-155 levels and epilepsy.
Objective:
The meta-analysis evaluates to assess and compare the levels of miR-155 in the brain tissue and serum of epilepsy patients and healthy controls.
Methods:
The databases PubMed, Embase, Cochrane Library, CNKI, VIP, and WanFang DATA were searched from inception until Dec 30, 2024 by two researchers. The relative expression level of miR-155 in the tissues or serum was the primary outcome of the search. After extracting data independently, the two researchers used the Cochrane Collaboration's tool for assessing risk of bias. All data were analyzed using Review Manager (V.5.4.1) statistical software.
Results:
This meta-analysis (nine studies, 394 patients) reveals elevated miR-155 in epilepsy patients vs. controls (SMD = 1.62, p = 0.001), especially in brain tissue. Subgroups confirm consistency across ages/regions. Subgroup analysis revealed no significant differences by country (p = 0.31), age category (p = 0.63) and sample source (p = 0.15), indicating robust consistency of the primary findings. MiR-155 may serve as a neuroinflammatory biomarker in epilepsy.
Conclusion:
Compared to healthy controls, the relative expression level of miR-155 in the brain tissue or serum of epilepsy patients increased.
Systematic Review Registration:
https://www.crd.york.ac.uk/prospero/, identifier: CRD42024558255.
Insights
MicroRNA-155 (miR-155) levels are elevated in epilepsy patients, indicating its role in neuroinflammation. This finding suggests miR-155 may serve as a potential biomarker for epilepsy diagnosis and management.
Area of Science:
- Neuroscience
- Molecular Biology
- Biomarker Discovery
Background:
- Neuroinflammation is implicated in epilepsy development and progression.
- MicroRNA-155 (miR-155) is a key regulator of inflammatory responses and is upregulated in neuroinflammatory conditions.
- This study investigates the role of miR-155 in epilepsy.
Purpose of the Study:
- To compare miR-155 expression levels in epilepsy patients versus healthy controls.
- To assess the correlation between miR-155 levels and epilepsy.
- To evaluate miR-155 as a potential biomarker for epilepsy.
Main Methods:
- A meta-analysis was conducted, searching multiple databases (PubMed, Embase, Cochrane Library, CNKI, VIP, WanFang DATA).
- Data from nine studies involving 394 patients were analyzed.
- Risk of bias was assessed using the Cochrane Collaboration's tool; statistical analysis was performed using Review Manager.
Main Results:
- Epilepsy patients exhibited significantly elevated miR-155 levels compared to healthy controls (SMD = 1.62, p = 0.001).
- Elevated miR-155 was particularly noted in brain tissue samples.
- Subgroup analyses confirmed consistency across different countries, age groups, and sample sources.
Conclusions:
- The relative expression of miR-155 is increased in the brain tissue or serum of epilepsy patients.
- MiR-155 shows potential as a neuroinflammatory biomarker for epilepsy.
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