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Pain experience and perception in individuals with Snijders Blok-Campeau syndrome

Don Daniel Ocay1,2, Philippe M Campeau3, Charles B Berde1,2,4

  • 1Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, United States.

Frontiers in Pain Research (Lausanne, Switzerland)
|August 29, 2025
PubMed

Insights

Caregivers reported that individuals with Snijders Blok-Campeau Syndrome (SNIBCPS) may have decreased pain sensation. This highlights the need for careful observation to ensure pain and injuries are not missed in these patients.

Area of Science:

  • Neurodevelopmental Disorders
  • Pain Perception Research
  • Pediatric Neurology

Background:

  • Snijders Blok-Campeau Syndrome (SNIBCPS) is a neurodevelopmental disorder with limited understanding of pain perception.
  • Anecdotal reports suggest altered pain sensation in individuals with SNIBCPS.

Purpose of the Study:

  • To investigate pain perception and response in individuals with SNIBCPS.
  • To understand the experiences of individuals with SNIBCPS regarding pain through proxy reports.

Main Methods:

  • A mixed-methods anonymous survey study involving 15 caregivers of individuals with SNIBCPS.
  • Utilized validated pain assessment tools including the Pediatric Pain Profile and Non-Communicative Children's Pain Checklist-Revised.

Main Results:

  • Nearly a quarter of caregivers reported insensitivity to hard impacts or pressure in individuals with SNIBCPS.
  • Findings indicate a range of pain expression behaviors and highlight past painful experiences.

Conclusions:

  • Increased awareness is needed for the proper examination of individuals with SNIBCPS.
  • Pain and injuries may be underreported in SNIBCPS, emphasizing the value of individualized parental observational scales for healthcare providers and caregivers.
Abstract

Keywords:
CHD3Snijders Blok-Campeau syndromeexperiencepainperception

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