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Related Concept Videos

Testing Water Quality01:14

Testing Water Quality

179
When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
179

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Related Experiment Video

Updated: Sep 9, 2025

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
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A System for the Qualitative Testing of Microfluidic Artificial Lungs Using Water.

Kartik Tharwani1, Gabriele K Seilo1, Jennifer Wang1

  • 1Department of Surgery, Joseph Potkay, University of Michigan, Ann Arbor, United States.

International Journal of Engineering and Technology : IJET
|August 29, 2025
PubMed
Summary

A new testing system uses water instead of blood to evaluate microfluidic artificial lungs (μALs). This cost-effective method safely assesses gas exchange, speeding up the development of next-generation artificial lung technology.

Keywords:
artificial lungsgas exchangemicrofluidicsqualitative testingwater-based testing

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Area of Science:

  • Biomedical Engineering
  • Respiratory Technology

Background:

  • Microfluidic artificial lungs (μALs) offer advanced respiratory support but face development hurdles.
  • Traditional blood-based testing for μALs is costly, time-consuming, and logistically complex.

Purpose of the Study:

  • To develop a safe, cost-effective, and efficient testing system for μALs.
  • To streamline the evaluation of gas exchange capabilities in μALs.

Main Methods:

  • Utilized water as a blood substitute for evaluating CO2 exchange via pH measurements.
  • Integrated sensors for pH and pressure into a single data logging system.
  • Demonstrated system modification for future blood-based oxygen exchange testing.

Main Results:

  • Successfully achieved qualitative gas exchange in distilled water using four μAL devices.
  • Measured pressure drop to assess fluidic resistance and operational safety.
  • Validated the system's potential for efficient μAL evaluation.

Conclusions:

  • The automated system provides a viable alternative to conventional blood-based μAL testing.
  • This innovation accelerates the development of next-generation artificial lung technology.
  • The system enhances safety and reduces costs in μAL research.