A System for the Qualitative Testing of Microfluidic Artificial Lungs Using Water

Microfluidic Artificial Lungs (μALs) are a promising technology for next generation artificial lungs, potentially offering improved treatment options for patients awaiting lung transplantation or requiring temporary respiratory support. Microfluidic artificial lungs are created using state-of-the-art manufacturing methods and can replicate the intricate flow networks of natural lungs and provide more efficient gas exchange. However, testing with blood is often labor intensive, logistically challenging, and expensive, which slows down the development of these technologies. We present a self-contained artificial lung testing system, addressing the challenges associated with traditional blood testing methods. To evaluate the artificial lungs' gas exchange capabilities, water is employed as a safe, cheap, and convenient alternative to blood. pH measurements serve as a practical measure of carbon dioxide exchange, opposed to blood-based carbon dioxide measurements. Sensors are integrated into a single data logging system to reduce human error. The system successfully achieved qualitative gas exchange capabilities by adding and removing carbon dioxide from distilled water using 4 devices. Integrated pressure sensors measured pressure drop to determine fluidic resistance, providing insights into safe operational parameters. Finally, the system was demonstrated to be easily modified to evaluate oxygen exchange in blood, providing an easy transition to the next step of testing. The automated artificial lung testing system presents an alternative to conventional blood-based testing methods, offering cost-effective, safe, and efficient qualitative evaluation of microfluidic artificial lungs. This innovation streamlines μAL development, allowing for the faster development of this next generation artificial lung technology.