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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
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Case report: Synchronous bladder and retroperitoneal paragangliomas: an extremely rare entity
Weitao Huang1, Yiming Liu2, Miaoping Zhou1
1Department of Radiology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.
Frontiers in Oncology
|August 29, 2025
Summary
Synchronous dual-site paragangliomas (PGLs) in the bladder and retroperitoneum are rare. This case emphasizes their distinct radiological features, which can mimic bladder cancer with metastasis, underscoring the need for accurate diagnosis.
Area of Science:
- Endocrinology
- Oncology
- Radiology
Background:
- Paragangliomas (PGLs) are rare neuroendocrine tumors arising from chromaffin cells.
- Synchronous occurrence of PGLs in multiple sites, such as the bladder and retroperitoneum, is exceptionally uncommon.
Observation:
- A 59-year-old female presented with abdominal distention.
- Imaging revealed a hypervascular bladder nodule and a retroperitoneal mass.
- These findings mimicked bladder cancer with lymph node metastasis.
Findings:
- Postoperative pathology confirmed dual-site paragangliomas.
- The multifocal and hypervascular nature of these tumors posed a diagnostic challenge.
- Radiological features, including CT and MRI, were key in identifying the lesions.
Implications:
- Accurate diagnosis of dual-site PGLs is crucial to avoid misdiagnosis as metastatic bladder cancer.
- Understanding the imaging characteristics of PGLs aids in appropriate treatment planning.
- This case highlights the importance of comprehensive evaluation for rare tumor presentations.
