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Advancements in biomedical rendering: A survey on AI-based denoising techniques
Elena Denisova1, Piergiorgio Francia2, Cosimo Nardi2
1University of Florence, via di Santa Marta 3, Florence, 50139, Italy; Imaginalis S.R.L., via Rodolfo Morandi 13, Sesto Fiorentino, 50019, Italy.
Computers in Biology and Medicine
|August 29, 2025
Summary
Healthcare professionals prefer AI-enhanced computed tomography (CT) images for better visualization. More experienced users show higher confidence and satisfaction with AI-assisted denoising, indicating its clinical potential.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Computer Science
Background:
- Deep learning-based denoising for Monte Carlo (MC) Path Tracing in computed tomography (CT) volume visualization shows promise but has inconsistent qualitative results.
- Evaluating the qualitative impact of AI on CT image denoising requires understanding user perception beyond standard metrics.
Purpose of the Study:
- To investigate the reasons for incongruent quantitative and qualitative assessments of deep learning-based denoising in CT volume visualization.
- To assess healthcare professionals' perceptions of AI-enhanced CT image and video quality, confidence, and clinical applicability.
Main Methods:
- A web-based SurveyMonkey questionnaire was distributed to radiologists, residents, orthopedic surgeons, and veterinarians.
- Participants evaluated randomized sections on AI-enhanced image/video quality, confidence in reference images, and clinical applicability.
- Seventy-four participants with varying experience levels (<1 to >5 years) completed the survey.
Main Results:
- A majority (77%) preferred AI-enhanced images over traditional MC estimates, with preference influenced by experience (adjusted OR 0.81).
- Participant experience correlated positively with confidence in AI-generated images and satisfaction with video previews (adjusted OR 0.96-0.98).
- Significant monotonic relationships were found between experience, confidence, and satisfaction.
Conclusions:
- AI post-processing holds potential for improving biomedical volume rendering in CT, particularly for experienced users.
- User preferences for AI-enhanced CT images may not always align with objective quality metrics like PSNR and SSIM.
- The study highlights the importance of qualitative assessments and user experience in evaluating AI's impact on medical image denoising.

