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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Updated: Sep 9, 2025

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

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[Polyneuropathies - What are possible causes?]

Dieter Felix Heuß

    Deutsche Medizinische Wochenschrift (1946)
    |August 29, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Polyneuropathies affect over 5% of adults over 55, with symptoms like numbness and weakness. Early diagnosis and treatment are key to managing this common neurological condition.

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    Area of Science:

    • Neurology
    • Peripheral Nervous System Disorders

    Background:

    • Polyneuropathies are common neurological disorders, affecting 5-8% of individuals over 55.
    • Prevalence is increasing due to aging populations, diabetes mellitus, and neurotoxic drug use.
    • These conditions involve damage to multiple peripheral nerves, impacting motor, sensory, or autonomic functions.

    Purpose of the Study:

    • To describe the diverse etiologies of polyneuropathies.
    • To present a diagnostic procedure for investigating polyneuropathy causes.
    • To highlight the importance of early diagnosis for treatment and prevention of complications.

    Main Methods:

    • Review of polyneuropathy causes, including metabolic, toxic, and genetic factors.
    • Description of a diagnostic approach for etiological investigation.
    • Consideration of age-related nerve fiber loss as a contributing factor.

    Main Results:

    • Polyneuropathies manifest with sensory symptoms (numbness, pain) and motor deficits (weakness, gait disturbance).
    • Symptoms often present insidiously, typically in a symmetrical "stocking pattern" affecting the feet.
    • Both nerve myelin and axons can be affected, with varied underlying causes.

    Conclusions:

    • Early diagnosis of polyneuropathies is crucial for effective management and preventing disease progression.
    • A systematic diagnostic approach is essential for identifying the underlying cause.
    • Age-related nerve changes can predispose individuals to or exacerbate polyneuropathies.