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Allergic Reactions

Allergic Reactions

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
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Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Sep 9, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Idiopathic Anaphylaxis.

Moshe Ben-Shoshan¹, Cem Akin², Victoria E Cook³

¹Division of Allergy, Immunology & Dermatology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada.

The Journal of Allergy and Clinical Immunology. in Practice

|August 29, 2025

Summary

Idiopathic anaphylaxis (IA) is a challenging diagnosis of recurrent hypersensitivity reactions without clear triggers. This case highlights a 17-year-old

Area of Science:

Immunology
Allergy
Clinical Medicine

Keywords:

Anaphylaxis Idiopathic anaphylaxis Mast cell Mast cell activation syndrome Tryptase

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Last Updated: Sep 9, 2025

Measuring Local Anaphylaxis in Mice

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Published on: May 31, 2021

Background:

Idiopathic anaphylaxis (IA) presents as recurrent, life-threatening hypersensitivity reactions lacking identifiable triggers, posing significant diagnostic and therapeutic challenges.
IA requires a comprehensive differential diagnosis, including IgE-mediated allergies, cofactor-dependent anaphylaxis, mast cell disorders, and systemic mimics.
Current management often involves prophylactic antihistamines and corticosteroids, with emerging evidence supporting anti-IgE therapy for refractory cases.