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Surgical Aortic Valve Replacement Combined With Coronary Artery Bypass Grafting in a Patient With Progeria

Simon Anquetil1, Mathieu Bignon2, Emré Belli3

  • 1Department of Pediatric Cardiology, CHU de Caen, Caen, France.

JACC. Case Reports
|August 29, 2025
PubMed

Insights

Surgical aortic valve replacement is a viable option for Hutchinson-Gilford progeria syndrome patients with severe aortic stenosis. This multidisciplinary approach addresses complex cardiac conditions in this rare, aging population.

Area of Science:

  • Cardiology
  • Genetics
  • Surgical Innovation

Background:

  • Hutchinson-Gilford progeria syndrome (HGPS) patients face increased mortality from calcific aortic stenosis.
  • Improved survival with lonafarnib therapy highlights the need for managing age-related comorbidities in HGPS.

Observation:

  • A 21-year-old male with HGPS presented with severe symptomatic calcific aortic stenosis and coronary artery disease.
  • This case represents the first successful combined surgical aortic valve replacement and coronary artery bypass grafting in an HGPS patient.

Findings:

  • Surgical aortic valve replacement, despite anatomical and procedural challenges, proved to be a feasible treatment.
  • A multidisciplinary team successfully managed this high-risk patient.

Implications:

  • Surgical valve replacement should be considered for HGPS patients when less invasive options are unsuitable.
  • Optimizing outcomes in this rare population necessitates a collaborative, specialized approach.
Abstract

Keywords:
cardiovascular diseasecoronary artery bypassvalve replacement

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