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Summary: multiple primary cancers in Denmark, 1943-80.

H H Storm, O M Jensen, M Ewertz

    National Cancer Institute Monograph
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Cancer survivors do not have a general increased risk of developing a second primary cancer. However, specific cancer sites and treatments, like radiotherapy, may elevate risks, particularly in younger patients and long-term survivors.

    Area of Science:

    • Oncology
    • Epidemiology
    • Cancer Research

    Background:

    • Understanding the risk of second primary cancers is crucial for cancer patient management.
    • Previous studies have yielded varying results on cancer patient susceptibility to new malignancies.

    Purpose of the Study:

    • To investigate the risk of developing a second primary cancer among a large cohort of Danish cancer patients.
    • To identify factors influencing second primary cancer development, including time since diagnosis, age, and potential common etiologies.

    Main Methods:

    • Analysis of 171,749 men and 208,192 women diagnosed with cancer between 1943 and 1980 in the Danish Cancer Registry.
    • Inclusion of patients surviving at least 2 months, accumulating over 1.7 million person-years of observation.
    • Calculation of relative risks (RR) for second primary cancers, with adjustments for underreporting.

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    Main Results:

    • The overall RR for a second primary cancer at a different site was 0.99 (adjusted to 1.06).
    • RR increased with time, from 0.94 in the first decade to 1.13 at 30 years.
    • Elevated risks observed for common etiology sites (e.g., smoking-related cancers) and specific treatment exposures (e.g., radiotherapy and subsequent cancers).
    • Patients diagnosed before age 20 had a significantly increased risk of second cancers.

    Conclusions:

    • Cancer patients generally do not exhibit a heightened susceptibility to new malignant tumors.
    • Specific risk factors, such as shared etiologies and cancer treatments, can increase the likelihood of developing a second primary cancer.
    • The study highlights the importance of long-term surveillance for cancer survivors, particularly those treated with radiotherapy or diagnosed at a young age.