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Updated: Sep 9, 2025
Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
Published on: July 16, 2021
Geographic distribution of amyotrophic lateral sclerosis-related genes: a systematic review
Beliu García-Parra1, Josep M Guiu2,3, Mónica Povedano1,4
1Clinical Neurophysiology Section - Neurology Service, Bellvitge University Hospital - Bellvitge Health Sciences Campus, University of Barcelona, Barcelona, Spain.
Introduction:
Amyotrophic lateral sclerosis (ALS) is a rare motor neuron disease. There is no effective treatment, but disease-modifying therapies do exist. Objective. To identify the geographical distribution of ALS-related genes.
Methods:
A systematic review was conducted according to the PRISMA 2020 guidelines in PubMed and Web of Science. Inclusion criteria: patients with ALS, no age or gender restriction, English and Spanish languages, studies published until 31 July 2025.
Results:
Thirty-eight results were obtained, 32 were selected, 19 articles were assessed for eligibility, and 8 articles were included from databases. Three articles recommended by clinical experts were added, so 11 results were reviewed. This research showed that published articles on the geographic distribution of ALS-related genes are limited, particularly for underrepresented regions such as Africa.
Conclusion:
The findings demonstrate the need for intensified international research to improve knowledge of the genetic epidemiology of ALS.
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