Interaction of cis-diamminedichloroplatinum (II) with mitochondrial phosphate carrier

Effect of cis-Pt(II) on mitochondrial phosphate transport has been studied. The inhibition of transport by cis-Pt(II) is demonstrated by the effect of the drug on mitochondrial phosphate-induced swelling and respiration. A diminished 14C-NEM binding to 33 kD mitochondrial protein in the presence of cis-Pt(II) suggests that cis-Pt(II) inhibits mitochondrial phosphate transport by a direct interaction with mitochondrial phosphate carrier.