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Assessing diagnostic delay in Ewing sarcoma: A single tertiary center analysis

Yordan S Ivanov1, Ivo V Ivanov1, Karina A Atanasova-Ivanova1

  • 1Medical University of Sofia, Sofia, Bulgaria.

Folia Medica
|August 30, 2025
PubMed
Abstract

Keywords:
early diagnosis Ewing diagnosis delay patient outcome sarcoma

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...