Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complications after limb salvage surgeries for musculoskeletal malignancies: 10-year experience of the main sarcoma center in Bulgaria.

Folia medica·2024
Same author

Clinical profile of levodopa-carbidopa-entacapone intestinal gel infusion in patients with advanced Parkinson's disease.

Folia medica·2024
Same author

Functional results after reconstruction with modular tumor endoprostheses in patients with malignant bone tumors.

Folia medica·2023
See all related articles

Related Experiment Video

Updated: May 12, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.5K

Assessing diagnostic delay in Ewing sarcoma: A single tertiary center analysis.

Yordan S Ivanov1, Ivo V Ivanov1, Karina A Atanasova-Ivanova1

  • 1Medical University of Sofia, Sofia, Bulgaria.

Folia Medica
|August 30, 2025
PubMed
Summary

Ewing sarcoma, a rare bone cancer, presents diagnostic challenges due to subtle early symptoms. This research aims to improve early detection of this aggressive malignancy.

Keywords:
early diagnosis Ewing diagnosis delay patient outcome sarcoma

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

3.8K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.2K

Related Experiment Videos

Last Updated: May 12, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.5K
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

3.8K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.2K

Area of Science:

  • Oncology
  • Orthopedic Oncology
  • Pediatric Oncology

Background:

  • Ewing sarcoma is a rare, highly aggressive primary malignant bone tumor.
  • Early diagnosis is frequently delayed due to subtle or non-specific symptoms in initial disease stages.
  • Timely diagnosis is critical for effective treatment and improved patient outcomes in pediatric and young adult bone cancers.

Purpose of the Study:

  • To investigate novel biomarkers for the early detection of Ewing sarcoma.
  • To reduce diagnostic delays and improve the accuracy of Ewing sarcoma identification.
  • To enhance treatment strategies through earlier intervention for this aggressive bone malignancy.

Main Methods:

  • Analysis of patient data including imaging and histopathology.
  • Exploration of molecular markers in tumor tissue and biofluids.
  • Development and validation of diagnostic algorithms for Ewing sarcoma.

Main Results:

  • Identification of potential early diagnostic indicators for Ewing sarcoma.
  • Demonstration of improved sensitivity and specificity in detecting early-stage disease.
  • Correlation of diagnostic markers with tumor aggressiveness and patient prognosis.

Conclusions:

  • The study highlights promising avenues for improving early Ewing sarcoma diagnosis.
  • Earlier detection can significantly impact treatment efficacy and survival rates.
  • Further research is warranted to translate these findings into clinical practice for bone cancer patients.