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Organic Afterglow Emitters for Visual Observation of Hydrogel Formation in Biomedical Systems
Zhe Mo1, Tengyue Wang1, Qianqian Yan1
1State Key Laboratory of Organometallic Chemistry and Shanghai Hongkong Joint Laboratory in Chemical Synthesis, Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Ningbo Zhongke Creation Center of New Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. China.
New organic emitters enable visual confirmation of biomedical hydrogel formation and precise localization. This gelation-induced afterglow technology offers enhanced control and visibility for hydrogel applications.
Area of Science:
- Biomaterials Science
- Organic Chemistry
- Photophysics
Background:
- Biomedical hydrogels require precise delivery and site-specific gelation for optimal efficacy.
- Current methods for confirming hydrogel formation and localization lack reliability and visual confirmation.
Purpose of the Study:
- To develop organic afterglow emitters for visualizing biomedical hydrogel formation and localization.
- To engineer emitters with tunable properties for enhanced afterglow performance in soft matter.
Main Methods:
- Design and synthesis of organic afterglow emitters with controlled phosphorescence and nonradiative decay rates.
- Incorporation of emitters into biomedical hydrogels and evaluation of afterglow properties.
- Investigation of oxygen diffusion and concentration effects on emitter performance within hydrogels.
Main Results:
- Emitters exhibited no afterglow in liquid state but showed bright, persistent afterglow (lifetimes up to 15.82 s) upon hydrogel formation.
- Gelation-induced afterglow provided high on/off contrast for visual confirmation and localization.
- Reduced oxygen diffusion and concentration within hydrogels significantly decreased the quenching rate, enabling afterglow.
Conclusions:
- A novel afterglow-based approach for visualizing hydrogel formation and localization was demonstrated.
- The study offers an innovative strategy for achieving high-performance organic afterglow in soft matter systems.
- This technology enhances the reliability and precision of biomedical hydrogel applications.
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