Association between obstructive sleep apnoea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease
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View abstract on PubMed
Summary
This summary is machine-generated.Obstructive sleep apnea (OSA) is independently associated with advanced liver fibrosis in patients with suspected nonalcoholic fatty liver disease (NAFLD). This finding was confirmed using gold-standard diagnostic tools in a biopsy-proven cohort.
Area Of Science
- Hepatology
- Sleep Medicine
- Internal Medicine
Background
- Obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) are prevalent conditions.
- Previous studies on the association between OSA and liver fibrosis often used noninvasive tools or focused on specific patient groups.
- The relationship between OSA and liver fibrosis in patients with biopsy-proven NAFLD requires further investigation.
Purpose Of The Study
- To determine if obstructive sleep apnea (OSA) is associated with liver fibrosis in patients suspected of having nonalcoholic fatty liver disease (NAFLD) who were referred for liver biopsy.
- To investigate the association using gold-standard diagnostic methods for both conditions.
Main Methods
- Prospective inclusion of 97 patients undergoing percutaneous liver biopsy for suspected NAFLD.
- In-lab polysomnography to diagnose moderate to severe OSA (apnea-hypopnea index ≥15 events/h).
- Liver fibrosis staging using the NASH-CRN scoring system, with advanced fibrosis defined as F≥3.
Main Results
- 40 patients had advanced fibrosis, and 63 had moderate to severe OSA.
- Prevalence of moderate to severe OSA was significantly higher in patients with advanced fibrosis (82%) compared to those with F0-2 fibrosis (52%; p<.0037).
- Moderate to severe OSA remained independently associated with advanced fibrosis (OR 3.48; p=.045) after adjusting for covariates. Nocturnal hypoxia markers also showed association, but OSA was not linked to steatosis or NASH.
Conclusions
- An independent association between obstructive sleep apnea (OSA) and liver fibrosis was confirmed in a multicenter cohort of biopsy-proven NAFLD patients.
- The study utilized gold-standard diagnostic tools for both OSA and NAFLD, strengthening the findings.
- These results highlight the importance of considering OSA in the management of NAFLD patients with liver fibrosis.
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