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Updated: Sep 9, 2025

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes
Published on: April 13, 2018
Chromosomal Instability and Chromoanagenesis as Forces for Genomic Evolution
Maikel Castellano-Pozo1,2, Valentine Comaills3
1Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Seville-CSIC, Junta de Andalucía, Seville, Spain. mcastellano2@us.es.
Abstract:
Advances in sequencing techniques have revealed extreme chromosomal diversity and underscored the importance of chromoanagenesis in macroevolution, speciation, and the context of cancer and tumor progression. Evolution is essential for adapting to the environment, preparing for future pressures, ensuring survival, and generating diversity. Here, we discuss some events like chromothripsis and other chromosomal rearrangements, emphasizing their roles as driving forces in genomic evolution from cancer to speciation.
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