Targeting Myeloperoxidase in Disease Pathogenesis: Emerging Roles of Natural Products in Therapeutic Modulation

Area of Science:

• Biochemistry and Molecular Biology
• Pharmacology
• Immunology

Background:

• Myeloperoxidase (MPO) is a key enzyme in inflammation and oxidative stress.
• Dysregulated MPO activity is implicated in cardiovascular, immune, and malignant diseases.
• Therapeutic targeting of MPO remains underexplored despite its pathological roles.

Purpose of the Study:

• To explore molecular pathways of MPO in disease pathogenesis.
• To review natural compounds and traditional medicines that modulate MPO activity.
• To provide a framework for developing novel MPO-targeted therapies.

Main Methods:

• Literature review of MPO's role in disease.
• Compilation and categorization of natural products affecting MPO function.
• Analysis of molecular mechanisms underlying MPO modulation by natural compounds.

Main Results:

• Detailed pathways linking dysregulated MPO to disease progression are outlined.
• A comprehensive list of natural compounds (polyphenols, flavonoids, TCMs) with MPO-modulating effects is presented.
• Evidence for the anti-oxidant and anti-inflammatory properties of these compounds is discussed.

Conclusions:

• Natural compounds offer promising therapeutic avenues for MPO-related diseases.
• Understanding MPO modulation by natural products can guide novel drug discovery.
• Targeting MPO presents a viable strategy for diverse inflammatory and degenerative conditions.