Related Experiment Video
Updated: Sep 9, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Linear correlation between white blood cell counts and the progression and prognosis of acute kidney injury
Honghua Liu1, Qiao Gu1, Yuhe Zhao1
1The Emergency Department of Affiliated Central Hospital of Chongqing University of Technology, The Seventh People's Hospital of Chongqing, China.
Abstract:
IntroductionWhite blood cell count, a cost-effective blood test marker, is used extensively for the diagnosis and prognosis of diseases. Nevertheless, its association with the progression and prognosis of acute kidney injury remains unclear.MethodsA retrospective analysis was conducted using data from a multicenter randomized trial on an acute kidney injury early warning system. Univariate analysis, multivariate logistic regression, and smooth curve fitting were used to evaluate the association between the white blood cell count and the progression and prognosis of acute kidney injury.ResultsA total of 5471 patients were included in the study. White blood cell counts were significantly associated with 14-day acute kidney injury progression (adjusted odds ratio: 1.04, 95% confidence interval: 1.02-1.06, P < 0.01) and 14-day mortality (adjusted odds ratio: 1.06, 95% confidence interval: 1.04-1.09, P < 0.01). However, white blood cell counts were not associated with 14-day dialysis (adjusted odds ratio: 1.01, 95% confidence interval: 0.97-1.05, P = 0.77). Further curve fitting analysis found a linear correlation between white blood cell counts and 14-day acute kidney injury progression and 14-day mortality.ConclusionWhite blood cell counts had a significant linear correlation with 14-day acute kidney injury progression and 14-day mortality, but not with 14-day dialysis.
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury I: Introduction
Acute Kidney Injury III: Clinical Manifestations
Chronic Kidney Disease I: Introduction
Acute Kidney Injury V: Interprofessional Care

