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Published on: April 22, 2019
Pre-treatment PET/CT for head and neck squamous cell carcinoma: secondary analysis of a clinical trial
Lulia Kana1, Bassem Chamma1, Natasha Robinette2
1Wayne State University Department of Otolaryngology-Head and Neck Surgery, Detroit, MI, USA.
Objective:
This study aims to evaluate the influence of pre-treatment PET/CT imaging on survival outcomes in individuals with locally advanced head and neck squamous cell carcinoma (HNSCC) STUDY DESIGN: Secondary analysis of the Radiation Therapy Oncology Group 0522 trial.
Setting:
Phase III randomized clinical trial with multi-institutional enrollment.
Methods:
Of the 940 patients enrolled, 891 met inclusion criteria and were included in the analysis. Overall survival, locoregional failure, distant metastasis, and progression-free survival were assessed using Kaplan-Meier and cumulative incidence models. Subgroup analyses were performed based on primary cancer site and p16 status.
Results:
Patients who underwent pre-treatment PET/CT had improved overall survival compared to those who did not in unadjusted analyses (unadjusted HR 0.77, 95% CI 0.6-0.98) but this difference was no longer significant after adjusting for demographic and clinical characteristics (adjusted HR 0.89, 95% CI 0.68-1.18). Improved survival was also observed in participants with p16-negative oropharyngeal, larynx, and hypopharynx carcinoma who underwent pre-treatment PET/CT (unadjusted HR 0.72, 95% CI 0.52-0.99) but significance was lost after adjustment (adjusted HR 0.82 95% CI 0.57-1.18). No significant differences were found in progression-free survival, locoregional failure or distant metastasis in the overall or subgroup analyses.
Conclusion:
Pre-treatment PET/CT imaging was not independently associated with improved survival outcomes in adjusted analyses. After adjustment, pre-treatment PET/CT did not independently influence survival outcomes.
